Endocrine Abstracts

Gonarthrosis is a severe problem of movement system. It is a restrictive health problem for modern human. And also; it is the other restrictive problem which coexistence of diabetes mellitus (DM) and gonarthrosis. Perhaps; an other parameter that is deserved to research for this coexistence is metabolic syndrome. Today, relationship between this clinical conditions are clear enough. And also two lobotuary parameters as Leptin and Nesfatin-1 are an other headstone for obesity a...

Osteoarthritis is a great public health problem indiscriminately; ie goanrthritis, coxarthritis or dejenerative spine diseases. Osteoarthritis is focude sixth decades in elderly people, espicially in women. Many studies assingned the efficiancy of Diabetes Mellitus in the etiology of Osteoarthritis. Correlations between bone-destructive characteristics and carbohydrate metabolism errors is now quite accused in this clinical views. A comparing between Diabetes Mellitus Type 1 a...

Diaserein is used in the spesific and long-term treatment of degenerative joint diseases (as osteoarthritis). In vitro studies have showed that Diaserein and its active metabolyte Rheinin inhibate production and activity of interleukin-113 (IL-113), some proinflamatuar and pro-catabolic cytokines. Interleukin-113 play important role to trigger production of more pro-inflamatuar factors as cytokines, cyclo-oxygeneas, prostogalandines, nitric oxide, matrix metalloprotei...

DHEA and its sulphate derivative DHEA-sulphate (DHEA-s) are major androgen hormones of adrenal origin. The purpose of this study was to investigate DHEA-s levels in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and to determine whether DHEA-s levels are a useful marker in the diagnosis of hypogonadotropic hypogonadism. 91 subjects, 31 male patients diagnosed with IHH (mean age 19.7±2.6 years) and 60 healthy males (mean age 20.7±2.6 years) as a con...

Introduction: In rheumatological diseases have been observed in a rate of 0.8% of non-traumatic insufficiency fractures. The most common sites of insufficiency fractures are pelvis, sacrum, tibia, the sections near to the insertion of the fibula, calcaneus and buttocks. Generally, bone – joint involvement in rheumatic diseases and osteoporosis connected with prolonged use of corticosteroids prepares the ground for these insuffiency fractures. In this case, We aimed to pre...

Familial hypocalciuric hypercalcemia is an inherited disease caused by inactivating heterozygous mutations in the gene encoding calcium-sensitive receptors, that affects calcium metabolism and generally follows a benign course. It must be also considered in the differential diagnosis of hyperparathyroidism. Six patients presenting to our internal diseases clinic between January, 2010, and June, 2015, were evaluated in terms of clinical and biochemical parameters. The youngest ...

Insulinoma is generally a rare benign tumor of the pancreas islet cell. The typical clinical symptom of insulinoma are repetitive hypoglycemia attacks. Insulinoma with coexisting diabetes is extremely rare condition, We aim to present a case with insulinoma conmomittant with type 2 diabetes mellitus.Case report: A 65-year-old woman diagnosed with type 2 diabetes mellitus was admitted by our internal medicine clinic. She complained from perspiration and t...

Introduction: The effects of sex steroids on lymphocytes count and functions are well known and it is propounded that autoimmune diseases more common in women. NLO index is an indicator of inflammative situation. In this study, it has been aimed that neutrophil/lymphocytes ratio (NLO) calculation by determining neutrophil/lymphocytes values in patients who diagnosed as hypogonadotropic hypogodanism and searching that whether there is significant difference between healthy grou...

Sheehan’s syndrome (SS) may be defined as development of anterior pituitary ischemic necrosis, first of which is caused by failure to meet the blood build-up required due to pituitary expansion secondary to lactotroph cell proliferation during pregnancy. Vasospasm, thrombosis and vascular compression of hypophyseal arteries have been described among the possible causes of SS. Additionally, expansion of pituitary gland, small sella, disseminated intravascular coagulation (...

Aim: Most diabetic patients suffer from vascular thrombotic complications. Alterations in platelet size are associated with atherosclerotic complications in patients with diabetes. The aim of study is to determine the relationship between mean platelet volume (MPV) and microvascular complications in type 2 diabetic patients.Materials and methods: Seventy-nine type 2 diabetic patients (mean age 51.0±10.8 years and BMI 31.0±5.5 kg/m2),...